Table 2.

JAK usage among the common cytokine receptor families.

Cytokine Receptor Family	Cytokines Affected	JAK Usage
Type I Cytokine Receptors
Common y Chain (CD132)	IL-2, IL-4, IL-7, IL-9, IL-13, IL-15, IL-21	JAK1, JAK3
Common Chain β (CD131)	IL-3, IL-5, GM-CSF (CSF2), EPO, TPO	JAK2
gp130 (CD130)	IL6, IL-11, IL-12, IL-23, IL-27, LIF, OSM	JAK1, JAK2, TYK2
Type II Cytokine Receptors
Interferon αβ Receptor	IFNα/β	JAK1, TYK2
Interferon γ Receptor	IFNγ	JAK1, JAK2
Type Ill Interferons	Type IIIIFN	JAK1, TYK2
IL-10 Receptor	IL-10, IL-20, IL-22, IL-28	JAK1
Other Cellular Receptors
BCR	B-cells	BTK