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. 2021 Jul 29;12:719810. doi: 10.3389/fimmu.2021.719810

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Copyright © 2021 Moström, Scheef, Sprehe, Szeltner, Tran, Hennebold, Roberts, Maness, Fahlberg and Kaur

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T lymphocyte changes in ZIKV-infected macaques. (A) T and γδ T lymphocytes in uninfected (n = 9) (grey) and ZIKV-infected (n = 9) decidual leukocytes. In the ZIKV-infected group, animals with detected amniotic fluid transmission displayed in blue and non-transmitters in red (B) Decreased activation of CD4+ T memory in the ZIKV-infected group. (C) Decreased activation of CD8+ T memory in the ZIKV-infected group. (D) Decreased activation of γδ T lymphocytes in the ZIKV-infected group. (E) Decreased decidual γδ T lymphocyte subset activation in ZIKV-infected macaques. P-values < 0.05 (unpaired t-test) shown on the plots.