FIGURE 4.

3D‐SIM images of mouse glomeruli. A, CLDN5 focally co‐localized with nephrin along the FS in PBS‐treated control mice. Similar to human biopsies, glomeruli of mice treated with nephrotoxic serum (NTS) showed extended CLDN5‐positive lines at the FS in areas of effaced podocyte foot processes. Panel B, shows focal CLDN5 localization to effaced FS in mice of the uninephrectomy deoxycorticosterone acetate (DOCA) salt hypertension mouse model compared with UNX controls. The scale bar indicates 2 µm