Skip to main content
. 2021 Jun 21;25(16):7948–7960. doi: 10.1111/jcmm.16724

FIGURE 5.

FIGURE 5

Nrf2 is involved in the regulation of cellular oxidation levels and attenuated oral epithelial antifungal immunity in the CSE‐treated Calbicans and Leuk1 co‐culture model. A, ROS fluorescence, MDA content, SOD activity and GSH/GSSG ratio were detected when Nrf2 was silenced in CSE‐treated co‐cultured cells. B, Microscopic view and semiquantitative analysis of Candida albicans colonies in different groups. C, Cytokine (IL‐6 and TNF‐α) levels in the supernatant were measured using ELISA kits. Each bar represents the mean ± SD. *P < .05, **P < .01, compared between two groups. CSE: cigarette smoke extract; Calbicans: Candida albicans; control: CSE‐treated Calbicans and Leuk1 co‐culture group; ROS: reactive oxygen species; MDA: malondialdehyde; SOD: superoxide dismutase; GSH/GSSG: reduced glutathione/oxidized glutathione; SFN: sulphoraphane