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. 2021 Jun 25;25(16):8028–8038. doi: 10.1111/jcmm.16734

FIGURE 4.

FIGURE 4

Circ_0002984 acts as a sponge of miR‐326‐3p. A, The putative binding sites between circ_0002984 and miR‐326‐3p. B, miR‐326‐3p expression in VSMCs transfected with miR‐326‐3p mimics or inhibitors. C, The luciferase activity of circ_0002984 WT and circ_0002984 MUT was detected in VSMCs. D, RIP assay was conducted to determine the interaction between circ_0002984 and miR‐326‐3p. E, The expression of miR‐326‐3p in VSMCs treated with various doses of ox‐LDL for 24 h was assessed. F, The expression of miR‐326‐3p in VSMCs treated with 100 µg/mL ox‐LDL for various times. G, Expression of circ_0002984 in VSMCs. Cells were treated with 100 µg/mL ox‐LDL, ox‐LDL +circ_0002984‐OE or ox‐LDL +circ_0002984‐OE +miR‐326‐3p mimics. H, The expression of miR‐326‐3p in VSMCs. I, Correlation between miR‐326‐3p and circ_0002984 in human patients. Compared with the control group, *P < 0.05; compared with the IgG group, *P < 0.001