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. 2021 Jul 29;12:639878. doi: 10.3389/fphar.2021.639878

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Copyright © 2021 Wang, Dai, Huang, Zhang, Huang, Wang, Ye, Wu, Zhang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mTORC1 pathway inhibition alleviated the glomerular damage in TCE sensitization. (A) mTORC1 inhibitor (rapamycin, RAPA) was applied to mice by intraperitoneal injection at 40 mg/kg 2 h before each challenge. (B) Phosphorylation process of mTOR signaling molecules were almost blocked and the proapoptotic molecules Bax and caspase-3 were also declined in RAPA + TCEpos group according to western blot bands (n = 3 per group). (C) The pathological changes of glomeruli were improved dramatically in mice from RAPA + TCEpos group. (D) The representative photograph of TUNEL staining showed less dead glomerular cells in RAPA + TCEpos group.