TABLE 1.
Sensitization rate and kidney impairment incidence in mice.
| Groups | Mice (n) | Score | Rate (%) | ||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | Sensitization | Kidney impairment | ||
| Blank control | 10 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Vehicle control | 10 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| TCE treatment | 40 | 25 | 9 | 4 | 2 | 37.5 (15/40) | 35.0 (14/40) |
| TCEpos | 15 | 9 | 4 | 2 | |||
| TCEneg | 25 | 25 | |||||
| RAPA + TCE treatment | 40 | 26 | 11 | 3 | 0 | 35.0 (14/40) | 15.0 (6/40) |
| RAPA + TCEpos | 14 | 11 | 3 | 0 | |||
| RAPA + TCEneg | 26 | 26 | |||||
| CTSLinh + TCE treatment | 40 | 27 | 9 | 4 | 0 | 32.5 (13/40) | 12.5 (5/40) |
| CTSLinh + TCEpos | 13 | 9 | 4 | 0 | |||
| CTSLinh + TCEneg | 27 | 27 | |||||
CTSL, cathepsin L; inh, inhibitor; TCE, trichloroethylene; pos, positive; neg, negative; RAPA, rapamycin.