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. 2021 Jul 28;6(31):20192–20204. doi: 10.1021/acsomega.1c01763

Figure 7.

Figure 7

(A) The viability of CT-26 monolayer culture cells was measured using the trypan blue dye exclusion assay method. Effect of 5-Fu, SPION/NGO@PCL–LMWC, and 5-Fu-loaded SPION/NGO@PCL–LMWC alone or in combination with AMF HT (43 °C) on the (B) expression of the Bax gene, (C) expression of the Bcl-2 gene, (D) and the Bax/Bcl-2 mRNA ratio in CT-26 cells. For all experiments, the concentrations of 5-Fu, MNPs, and 5-Fu-loaded MNPs were 0.13, 6.5, and 6.5 μg/mL, respectively. Also, the AMF was applied for 6 min for the nanoparticles group and 17 min for the control groups [mean ± standard deviation (SD), n = 3]. Statistical significance is shown as *P < 0.05, and **P < 0.01, respectively.