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Schematic model for the role of RAPGEF2 in Aβ oligomer‐induced synaptic degeneration. In the AD hippocampus (right), synaptotoxic Aβ oligomers stimulate the upregulation of RAPGEF2 levels and lead to the activation of small GTPase Rap2. Rap2 activation, in turn, phosphorylates its downstream signalling target JNK. The Aβ oligomer‐mediated upregulation of RAPGEF2 induces the loss of excitatory synapses and subsequent memory impairment
