Table 4. Calculated Korsmeyer-Peppas (Values of n) of Different Nanocomposite Beads at pH 1.2 and 7.4.
| release exponent (n) | drug transport mechanism | drug release mechanism |
|---|---|---|
| n < 0.5 | Quasi-Fickian diffusion | nonswellable matrix diffusion |
| 0.5 | Fickian diffusion | |
| 0.5 < n < 1.0 | Anomalous (non-Fickian transport) | For both diffusion and relaxation (erosion) |
| 1.0 | Case II transport | Zero-order release |
| higher than 1.0 | Super case II transport | (relaxation/erosion) |
| Korsmeyer-Peppas (calculated value of n) | ||
| code | pH 1.2 | pH 7.4 |
| M6 | 0.2701 | 0.287 |
| M8 | 0.4643 | 0.207 |
| M12 | 0.1877 | 0.1786 |
| M16 | 0.1964 | 0.2159 |