FIGURE 4.

The integrin–complosome–metabolism network in the regulation of T‐cell effector function. Summary model depiction of the known cooperative actions of LFA‐1/integrins, the complosome, and key metabolic events that underly successful effector function induction in human CD4⁺ and CD8⁺ T‐cells. T‐cell receptor, growth factor receptor, and intrinsic inflammasome signals as well as negative/positive feedback loops (e.g., between generated metabolites and LFA‐1) have been omitted for simplicity