TABLE 2.
Selected microRNAs with function in skin biology
| MicroRNA | Function | Reference |
|---|---|---|
| Homeostasis and morphogenesis | ||
| miR‐34a | Induces differentiation. Anti‐proliferative function | 175 |
| miR‐34c | Suppresses differentiation, involved in senescence | 176 |
| miR‐125b | Represses stem cell differentiation and promotes stem cell renewal | 177 |
| miR‐184 | KC differentiation | 178 |
| miR‐203 | Repressor of p63. Regulator of keratinocyte differentiation | 179 |
| miR‐205 | Enhances migration | 180 |
| miR‐210 | Pro‐angiogenic. Cell‐cycle regulation. Hypoxa‐miR | 181 |
| Epigenetic targets | ||
| miR‐29 family | DNMT3A‐B, indirectly DNMT1 | 182 |
| miR‐145 | HDAC2 | 183 |
| miR‐200b | PCGF4 | 184 |
| miR‐200c | PCGF4 | 185 |
| miR‐221 | HDAC6 | 186 |
| Cancer | ||
| miR‐10b | Confers of stemness features to tumour cells in cSCCs | 90 |
| miR‐21 | OncomiR, anti‐apoptotic, pro‐survival | 187, 188 |
| miR‐27a | Targets EGFR | 189 |
| miR‐34a | Tumour‐suppressor miRNA, targets HMGB1 | 190 |
| Ageing | ||
| miR‐146a | Involved in fibroblast senescence via regulation of Smad4 | 191 |
| miR‐181a,b | Involved in senescence in keratinocytes and fibroblasts | 192, 193 |
| Fibrosis | ||
| miR‐21 | Fibroblast proliferation and transdifferentiation | 194 |
| miR‐29b | Regulator of collagen expression | 86, 87 |
| miR‐145 | Regulation of myofibroblast differentiation | 88, 89 |
Abbreviations: HDAC, Histone deacetylase; PCGF4, Polycomb group RING finger protein 4.