Table 2.
Results of logistic regression between mitochondrial DNA copy number and metabolic syndrome components
| Metabolic syndrome components | GCKD | CHRISa | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P‐value | OR | 95% CI | P‐value | |
| Model 1: adjusting for age and sex | ||||||
| Elevated WC (GCKD)/BMI (CHRIS) | 1.045 | 1.027–1.064 | 4.81 × 10 − 07 | 1.019 | 1.010–1.028 | 3.84 × 10 − 05 |
| Elevated triglycerides | 1.004 | 0.998–1.020 | 0.61 | 1.025 | 1.012–1.038 | 1.29 × 10 − 04 |
| Reduced HDL cholesterol | 1.006 | 0.990–1.023 | 0.46 | 1.028 | 1.013–1.043 | 2.77 × 10 − 04 |
| Elevated blood pressure | 1.054 | 1.005–1.102 | 0.0248 | 1.012 | 1.003–1.022 | 0.0139 |
| Elevated Hb1Ac (GCKD)/fasting glucose (CHRIS) | 1.012 | 0.995–1.029 | 0.16 | 1.013 | 1.001–1.025 | 0.0385 |
| Model 2: adjusting for age, sex, smoking, eGFR and UACR | ||||||
| Elevated WC (GCKD)/BMI (CHRIS) | 1.045 | 1.027–1.064 | 6.69 × 10 − 07 | 1.017 | 1.008–1.026 | 1.58 × 10 − 04 |
| Elevated triglycerides | 0.999 | 0.983–1.015 | 0.89 | 1.020 | 1.007–1.034 | 0.0023 |
| Reduced HDL cholesterol | 1.001 | 0.984–1.018 | 0.92 | 1.024 | 1.009–1.040 | 0.0016 |
| Elevated blood pressure | 1.044 | 0.995–1.093 | 0.07 | 1.012 | 1.002–1.022 | 0.0239 |
| Elevated Hb1Ac (GCKD)/fasting glucose (CHRIS) | 1.010 | 0.992–1.027 | 0.28 | 1.010 | 0.998–1.023 | 0.09 |
Odds ratios (OR) are given for decrease of 10 mtDNA copies. The bold values should point out which findings are statistically significant.
eGFR, estimated glomerular filtration rate; Hb1Ac, glycated haemoglobin; UACR, urine albumin‐to‐creatinine ratio; WC, waist circumference.
a
CHRIS study additionally adjusted for protocol, batch and kinship matrix (see Supplementary Material).