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. 2021 Feb 2;290(1):141–156. doi: 10.1111/joim.13234

Fig. 2.

Fig. 2

Chimeric PC‐mAb(T15) prevents accelerated atherosclerotic lesion formation. (a) Representative human endarterectomy specimen (n = 12) stained for phosphorylcholine (PC, yellow star) and macrophages (CD68, blue hash). (b) Representative cross sections of macrophages (MAC‐3) in cuffed arteries of ApoE3*Leiden mice receiving vehicle (control), human anti‐streptavidin (control IgG) or anti‐PC(T15) IgG after 3 days (n = 5/group). (c) Quantification of macrophages (t3). (d) Representative cross sections of cuffed arteries at day 14 (n = 9–10/group). Quantification of neointima (e), intima/media ratio (f), % lumen stenosis (g), % smooth muscle cells (h) and % macrophages. (i) Mean ± SD, Mann–Whitney; *P < 0.05, ***P < 0.001 and ****P < 0.0001.