TABLE 1.

PECOS criteria

	Inclusion	Exclusion
Participants	Human All ages and nationalities Diagnosis of mild/moderate/severe FVIII/FIX deficiency	Animal studies In vitro studies Other rare bleeding disorders Von Willebrand's Disease Acquired haemophilia
Exposures	+/‐ information on treatment regimen	PA or exercise interventions
Comparators	No comparators Subgroup categories within study population (eg age or severity) Control groups without haemophilia PA guidelines	Comparators not specified in inclusion criteria
Outcomes	Any assessment of habitual PA (ie retrospective audit, observation, self‐reported measures and objective measures) +/‐ information on bleeds (ie annualised joint bleed rate, other bleed scores, self or documented report of number/type/cause of bleed, etc.)	Outcomes not specified in inclusion criteria
Study design	Cross‐sectional, cohort and case‐control studies Longitudinal/prospective follow‐up studies Retrospective studies Pilot studies	Pre/post‐interventional studies Case reports Systematic/narrative reviews Conference abstracts/letters to the editor