FIGURE 2.

Mean PK and PD data following administration of a single dose of ONO‐7684 (Part A). Time course of mean ONO‐7684 concentrations (A), mean ratio‐to‐baseline values for FXI:C (B), and mean ratio‐to‐baseline values for aPTT (C). ONO‐7684 concentrations were not measured for placebo (fasted) and placebo (fed) groups and are, therefore, not presented in (A)aPTT, activated partial thromboplastin time; FXI:C, factor XI coagulation activity; LLOQ, lower limit of quantification; PD, pharmacodynamics; PK, pharmacokinetics