TABLE 2.
Summary pharmacokinetic parameters for subcutaneous (s.c.) and intradermal (i.d.) adalimumab administration in the per protocol study population
| Parameter | s.c. (n = 10) | i.d. (n = 9) | |||
|---|---|---|---|---|---|
| Mean (SD) | Median (range) | Mean (SD) | Median (range) | ||
| Cmax (μg/mL) | 3.3 (1.1) | 3.6 (1.5–4.8) | 4.4 (0.7) | 4.2 (3.6–5.5) | |
| Tmax (h) | not obtained | 120 (96–221) | not obtained | 95 (47–120) | |
| AUC0‐last (μg*h/mL) | 2189 (816) | 2005 (846–4019) | 2688 (869) | 2581 (1677–4094) | |
SD: standard deviation; Cmax: maximum plasma concentration; Tmax: time to reach Cmax; AUC: area under the plasma concentration–time curve