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Diuretic (A) and haemodynamic (B–D) effects of oral treatment with pecavaptan or tolvaptan during infusion of increasing dosages of arginine vasopressin (AVP). All data are mean of n = 9 ± standard error of the mean. CI, cardiac index; CO, cardiac output; Pl, placebo; TPR, total peripheral resistance; UV, urine volume. *P < 0.05; **P < 0.01; ***P < 0.001.
