TABLE 3.
Impact of decisive parameters on the frequency of systemic adverse events during VIT
| Parameter | Categories | No systemic reaction | Systemic reaction | OR (95% CI)a | p‐value | OR (95% CI)b | p‐value |
|---|---|---|---|---|---|---|---|
| Age at starting date of VIT | 1240 (93.0) | 93 (7.0) | 0.98 (0.96–1.00) | 0.09 | 0.99 (0.96–1.01) | 0.20 | |
| Antihypertensive treatment with β‐blockers and/or ACEI | No | 920 (92.6) | 74 (7.4) | 1.00 | 0.25 | 1.00 | 0.61 |
| Yes | 319 (94.4) | 19 (5.6) | 0.74 (0.43–1.22) | 0.87 (0.49–1.52) | |||
| Cardiovascular disease | No | 734 (92.1) | 63 (7.9) | 1.00 | 0.11 | .. | .. |
| Yes | 498 (94.3) | 30 (5.7) | 0.69 (0.43–1.08) | .. | |||
| Bee venom | No | 879 (95.8) | 39 (4.3) | 1.00 | <0.001 | 1.00 | <0.001 |
| Yes | 360 (87.0) | 54 (13.0) | 3.39 (2.20–5.27) | 3.35 (2.17–5.16) | |||
| Tryptasec | ≤11.4 µg/L | 1010 (93.2) | 74 (6.8) | 1.00 | 0.16 | .. | .. |
| >11.4 µg/L | 107 (89.2) | 13 (10.8) | 1.54 (0.83–2.90) | .. | |||
| Verified mastocytosisc | No | 1,144 (93.1) | 85 (6.9) | 1.00 | 0.41 | .. | .. |
| Yes | 29 (87.9) | 4 (12.1) | 1.71 (0.57–5.14) | .. | |||
| sIgE levels (bee venom) | >0.35–3.5 kU/l | 96 (85.0) | 17 (15.0) | 1.00 | 0.99 | .. | .. |
| >3.5–17.5 kU/l | 97 (85.1) | 17 (14.9) | 0.97 (0.46–2.06) | .. | |||
| >17.5 kU/l | 45 (84.9) | 8 (15.1) | 0.92 (0.34–2.31) | .. | |||
| sIgE levels (vespid venom) | >0.35–3.5 kU/l | 270 (94.1) | 17 (5.9) | 1.00 | 0.15 | .. | .. |
| >3.5–17.5 kU/l | 281 (96.9) | 9 (3.1) | 0.52 (0.22–1.17) | .. | |||
| >17.5 kU/l | 148 (97.4) | 4 (2.6) | 0.42 (0.12–1.17) | .. | |||
| Grading Ring‐Messmer (initial sting reaction) | 1&2 | 714 (93.3) | 51 (6.7) | 1.00 | 0.66 | .. | .. |
| 3&4 | 526 (92.6) | 42 (7.4) | 1.10 (0.72–1.69) | .. | |||
| Premedication with H1‐antihistamine | No | 606 (94.3) | 37 (5.8) | 1.00 | 0.07 | .. | .. |
| Yes | 634 (91.9) | 56 (8.1) | 1.67 (0.96–3.18) | .. | |||
| Up‐dosing protocol | Conventional | 104 (95.4) | 5 (4.6) | 1.00 | 0.50 | .. | .. |
| Rush, cluster, ultrarush | 1128 (93.1) | 84 (6.9) | 1.40 (0.54–4.23) | .. |
a
no adjustments.
b
multivariable model.
c
Data imputation for univariable model.