Table 3.

Statistical Summary of Ertugliflozin Exposure Comparison Between Healthy Japanese and Western Subjects in Cohort A

		Adjusted Geometric Means
Dose	Parameter	Japanese	Western	Ratio of Adjusted Geometric Means, %	90%CI for Ratio
1 mg	Cmax, ng/mL	17.9	16.6	107.59	87.61‐132.11
	AUClast, ng • h/mL	77.6	80.9	95.94	78.76‐116.87
5 mg	Cmax, ng/mL	91.6	93.9	97.47	79.38‐119.69
	AUClast, ng • h/mL	466	467	99.66	81.81, 121.40
	AUCinf, ng • h/mL	476	481	98.94	81.17‐120.61
25 mg	Cmax, ng/mL	429	536	80.04	65.18‐98.28
	AUClast, ng • h/mL	2365	2618	90.32	74.14‐110.02
	AUCinf, ng • h/mL	2402	2638	91.05	74.70‐110.99

AUC, area under the plasma concentration–time curve; AUC_inf, AUC from time 0 extrapolated to infinite time; AUC_last, AUC from time 0 to the time of last measurable concentration; CI, confidence interval; C_max, maximum observed plasma concentration.

Mixed‐effect model with dose, populations, and interaction term of dose by population as fixed effects, subject within population as random effect.