TABLE 1.

Investigational product administration and blood sampling times

Investigational product	Dose	CYPs/transporters of interest	Blood sampling time
Zanubrutinib	320 mg daily (160 mg b.i.d.)	Not applicable	Predose and 0.5, 1, 2, 3, 4, 6, 8, and 12 h postdose (Day 13 and Day 18)
Midazolam	2 mg	CYP3A	Predose and 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h postdose (Days 1–2, Days 14–15)
Warfarin	10 mg	CYP2C9 (for S‐warfarin)	Predose and 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24, 48, 72, 96, 120, and 144 h postdose (Days 1–7, Days 14–20)
Vitamin K	10 mg	Not applicable	NA
Omeprazole	20 mg	CYP2C19	Predose and 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h postdose (Days 5–6, Days 18–19)
Digoxin	0.25 mg	P‐gp	Predose and 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h postdose (Days 3–4, Days 16–17)
Rosuvastatin	10 mg	OATP1B1, OATP1B3, BCRP	Predose and 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24, and 48 h postdose (Days 3–4, Days 16–17)

Abbreviations: BCRP = breast cancer resistance protein; b.i.d. = twice daily; CYP = cytochrome P450; NA = not applicable; OATP = organic anion‐transporting polypeptide; P‐gp = P‐glycoprotein; PK = pharmacokinetic.