Figure 6.

Phosphorylated tau (P‐tau) levels in human CSF correlates with acetylcholinesterase (AChE) enzymatic activity. CSF samples were obtained from Alzheimer's disease (AD) patients treated with tideblusib (n = 14; open circles) or with a placebo compound (n = 5; closed circles), at baseline and at the end of the trial. (a) Correlation between CSF AChE enzymatic activity levels and P‐tau(P‐181 form) at the beginning of the treatment. (b) Box plot represents the difference between CSF AChE enzymatic activity levels at baseline and at the end of the treatment expressed as % over basal levels. *Significantly different (p <.05) from the control group, as assessed by the Student's t test. (c) Correlation of the changes in CSF AChE activity (panel B) with the changes on P‐tau levels (Figure 4) considering all AD patients (solid line), only placebo‐treated (small dotted line) or only tideglusib (long dotted line)