Table 3.
Treatment efficacy at posttreatment and 12‐month follow‐up
| Mean (SD) [95% CI]a | Mean (SD) [95% CI] | Time effect | Within‐group p value | ||||
|---|---|---|---|---|---|---|---|
| Outcome and time | N | WL | CBT | F (df) | Pre to Post | Pre to FU | Post to FU |
| Primary outcome | |||||||
| AMISOS‐R | 48.76 (2, 86.6)*** | *** | *** | .383 | |||
| Pre | 54 | 27.5 (4.8) [25.6–29.3] | 30.4 (4.2) [28.8–32.0] | ||||
| Post | 48 | 19.7 (6.8) [16.8–22.6] | 21.9 (7.0) [19.2–24.6] | ||||
| Follow‐up | 37 | 22.3 (8.3) [18.4–26.1] | 22.2 (8.4) [18.4–26.0] | ||||
| Secondary outcomes | |||||||
| CGI‐S | NaN | ||||||
| Pre | 54 | 5.0 (0.8) [4.7–5.3] | 5.6 (0.8) [5.3–5.8] | ||||
| Post | 49 | 3.5 (1.4) [2.9–4.0] | 4.7 (1.0) [4.3–5.0] | ||||
| Follow‐up | b | b | b | ||||
| CGI‐S therapist | NaN | ||||||
| Pre | 53 | 5.7 (0.7) [5.4–5.9] | 5.7 (0.6) [5.5–5.9] | ||||
| Post | 48 | 2.8 (1.0) [2.3–3.2] | 3.5 (1.4) [2.9–4.0] | ||||
| Follow‐up | b | b | b | ||||
| SCL‐90 | 31.00 (2, 81.9)*** | *** | *** | .107 | |||
| Pre | 54 | 147.0 (42.5) [130.8–163.1] | 182.8 (62.7) [159.0–206.5] | ||||
| Post | 47 | 116.5 (22.8) [106.7–126.3] | 156.5 (75.0) [127.6–185.5] | ||||
| Follow‐up | 37 | 133.6 (55.1) [108.0–159.1] | 142.2 (54.9) [117.4–167.0] | ||||
| EQ5‐D | 1.57 (2, 84.9) | .431 | .229 | .659 | |||
| Pre | 53 | 0.8 (0.2) [0.8–0.9] | 0.8 (0.1) [0.7–0.8] | ||||
| Post | 44 | 0.8 (0.2) [0.7–0.9] | 0.8 (0.2) [0.7–0.9] | ||||
| Follow‐up | 37 | 0.9 (0.1) [0.8–0.9] | 0.8 (0.2) [0.7–0.9] | ||||
| SDS Work | 10.76 (2, 82.6)*** | *** | *** | .914 | |||
| Pre | 54 | 4.0 (3.0) [2.8–5.1] | 6.0 (2.3) [5.1–6.9] | ||||
| Post | 46 | 2.6 (2.3) [1.6–3.6] | 4.2 (2.7) [3.1–5.3] | ||||
| Follow‐up | 37 | 2.3 (2.4) [1.2–3.4] | 4.3 (2.7) [3.1–5.5] | ||||
| SDS Social | 27.60 (2, 80.6)*** | *** | *** | .841 | |||
| Pre | 54 | 6.0 (2.0) [5.2–6.7] | 6.9 (1.7) [6.2–7.5] | ||||
| Post | 46 | 3.4 (2.1) [2.5–4.3] | 5.0 (2.7) [4.0–6.1] | ||||
| Follow‐up | 37 | 4.6 (3.0) [3.2–5.9] | 4.6 (3.1) [3.2–6.0] | ||||
| SDS Family | 29.20 (2, 82.7)*** | *** | *** | * | |||
| Pre | 54 | 6.4 (2.8) [5.4–7.5] | 8.0 (1.4) [7.5–8.6] | ||||
| Post | 46 | 4.0 (2.9) [2.8–5.3] | 6.1 (1.9) [5.4–6.9] | ||||
| Follow‐up | 37 | 4.4 (3.3) [2.9–6.0] | 4.6 (2.8) [3.4–5.9] | ||||
| SDS Total | 37.00 (2, 80.3)*** | *** | *** | .310 | |||
| Pre | 54 | 16.4 (5.8) [14.2–18.6] | 20.9 (3.9) [19.4–22.3] | ||||
| Post | 46 | 10.1 (5.9) [7.6–12.6] | 15.4 (6.1) [13.0–17.8] | ||||
| Follow‐up | 36 | 10.9 (7.0) [7.6–14.3] | 13.5 (8.0) [9.9–17.2] | ||||
| WHOQoL Social relationships | 4.44 (2, 79.1)* | * | .074 | .767 | |||
| Pre | 53 | 14.3 (2.8) [13.2–15.3] | 12.9 (2.5) [12.0–13.9] | ||||
| Post | 43 | 15.3 (2.2) [14.4–16.2] | 14.1 (3.0) [12.8–15.3] | ||||
| Follow‐up | 37 | 13.9 (2.9) [12.6–15.3] | 14.0 (2.8) [12.8–15.3] | ||||
| WHOQoL Environment | 4.11 (2, 80.3)* | * | *** | .140 | |||
| Pre | 53 | 16.7 (1.9) [16.0–17.5] | 14.9 (2.1) [14.1–15.7] | ||||
| Post | 43 | 16.8 (1.9) [16.0–17.6] | 15.8 (2.6) [14.7–16.8] | ||||
| Follow‐up | 37 | 16.8 (1.9) [15.9–17.7] | 16.4 (2.3) [15.4–17.5] | ||||
| WHOQoL Physical health | 13.07 (2, 79.1)*** | ** | *** | .216 | |||
| Pre | 53 | 14.9 (2.5) [13.9–15.9] | 13.1 (2.5) [12.1–14.0] | ||||
| Post | 44 | 16.3 (1.6) [15.6–17.0] | 14.1 (2.7) [13.0–15.3] | ||||
| Follow‐up | 37 | 16.3 (2.4) [15.3–17.4] | 14.9 (3.3) [13.5–16.4] | ||||
| WHOQoL Psychological health | 12.74 (2, 79.4)*** | ** | *** | .225 | |||
| Pre | 53 | 13.6 (2.0) [12.8–14.4] | 12.1 (2.3) [11.3–13.0] | ||||
| Post | 44 | 14.7 (1.2) [14.2–15.3] | 13.1 (2.6) [12.0–14.1] | ||||
| Follow‐up | 37 | 14.0 (2.6) [12.7–15.2] | 13.6 (2.5) [12.5–14.8] | ||||
| WHOQoL General health | 1.99 (2, 78.9) | .968 | .420 | .453 | |||
| Pre | 53 | 7.5 (1.4) [7.0–8.0] | 7.1 (1.5) [6.6–7.7] | ||||
| Post | 44 | 8.2 (1.1) [7.7–8.7] | 7.1 (1.9) [6.4–7.9] | ||||
| Follow‐up | 36 | 8.2 (1.3) [7.6–8.8] | 7.5 (1.9) [6.6–8.3] | ||||
| CGI‐I | NaN | ||||||
| Pre | NaN | NaN | NaN | ||||
| Post | 49 | 2.3 (0.8) [2.0–2.6] | 3.0 (1.0) [2.6–3.3] | ||||
| Follow‐up | b | b | b | ||||
| CGI‐I therapist | NaN | ||||||
| Pre | NaN | NaN | NaN | ||||
| Post | 48 | 2.0 (0.8) [1.7–2.4] | 2.3 (0.9) [1.9–2.7] | ||||
| Follow‐up | b | b | b | ||||
Abbreviations: AMISOS‐R, Amsterdam Misophonia Scale‐Revised; CBT, cognitive behavioral therapy; CGI‐I, Clinical Global Impression‐Improvement; CGI‐S, CGI Severity scale; EQ5‐D, five‐dimensional EuroQol; FU, follow‐up; NaN, Not a Number; QoL, quality of life; SCL‐90, Symptom Checklist‐90; SDS, Sheehan Disability Scale; WL, waiting list; WHOQoL‐BREF, WHO Quality of Life‐BREF.
a
For the waiting list condition in “Pre” data of T2 was used.
b
There was no CGI assessment at FU.
*
p < .05.
**
p < .01.
***
p < .001.