The effect of the formulation on the expression of several key genes implicated in atherosclerosis.
| Gene | Control | Formulation | % Change | p-Value | ||
|---|---|---|---|---|---|---|
| N | Mean ± SEM | N | Mean ± SEM | |||
| Abca1 | 6 | 1 ± 0.04 | 6 | 1.13 ± 0.07 | 13 (↑) | 0.139 |
| Ace | 5 | 1 ± 0.16 | 6 | 0.84 ± 0.18 | 16 (↓) | 0.516 |
| Apoa1 | 6 | 1 ± 0.04 | 6 | 0.94 ± 0.04 | 6 (↓) | 0.285 |
| Apob | 6 | 1 ± 0.04 | 6 | 1.00 ± 0.02 | 0 (-) | 0.977 |
| Apoe | 6 | 1 ± 0.07 | 6 | 1.05 ± 0.08 | 5 (↑) | 0.629 |
| Bax | 6 | 1 ± 0.08 | 6 | 1.07 ± 0.04 | 7 (↑) | 0.462 |
| Bcl2 | 5 | 1 ± 0.16 | 6 | 0.74 ± 0.11 | 26 (↓) | 0.210 |
| Bcl2a1a | 6 | 1 ± 0.24 | 6 | 0.47 ± 0.13 | 53 (↓) | 0.086 |
| Bcl2l1 | 6 | 1 ± 0.04 | 6 | 1.08 ± 0.09 | 8 (↑) | 0.441 |
| Bid | 6 | 1 ± 0.05 | 6 | 1.04 ± 0.02 | 4 (↑) | 0.512 |
| Birc3 | 6 | 1 ± 0.03 | 6 | 0.94 ± 0.05 | 6 (↓) | 0.325 |
| Ccl2 | 6 | 1 ± 0.12 | 6 | 0.84 ± 0.18 | 16 (↓) | 0.492 |
| Ccl5 | 6 | 1 ± 0.21 | 6 | 0.76 ± 0.09 | 24 (↓) | 0.329 |
| Ccr1 | 6 | 1 ± 0.35 | 4 | 0.50 ± 0.17 | 50 (↓) | 0.235 |
| Ccr2 | 6 | 1 ± 0.21 | 6 | 1.29 ± 0.18 | 29 (↑) | 0.313 |
| Cd44 | 6 | 1 ± 0.09 | 6 | 0.77 ± 0.05 | 23 (↓) | 0.051 |
| Cdh5 | 6 | 1 ± 0.05 | 6 | 0.98 ± 0.07 | 2 (↓) | 0.793 |
| Cflar | 6 | 1 ± 0.06 | 6 | 1.35 ± 0.09 | 35 (↑) | 0.009 |
| Col3a1 | 6 | 1 ± 0.16 | 6 | 1.25 ± 0.19 | 25 (↑) | 0.329 |
| Csf2 | 4 | 1 ± 0.32 | 2 | 0.77 ± 0.34 | 23 (↓) | NA |
| Ctgf | 6 | 1 ± 0.48 | 6 | 0.45 ± 0.07 | 55 (↓) | 0.310 |
| Cxcl1 | 6 | 1 ± 0.14 | 5 | 0.63 ± 0.08 | 37 (↓) | 0.049 |
| Eln | 6 | 1 ± 0.14 | 6 | 0.89 ± 0.12 | 11 (↓) | 0.576 |
| Eng | 6 | 1 ± 0.06 | 6 | 0.98 ± 0.06 | 2 (↓) | 0.858 |
| Fabp3 | 5 | 1 ± 0.07 | 6 | 0.88 ± 0.13 | 12 (↓) | 0.452 |
| Fas | 6 | 1 ± 0.06 | 6 | 1.11 ± 0.05 | 11 (↑) | 0.156 |
| Fga | 6 | 1 ± 0.04 | 6 | 0.92 ± 0.03 | 8 (↓) | 0.132 |
| Fgb | 6 | 1 ± 0.03 | 6 | 0.95 ± 0.03 | 5 (↓) | 0.240 |
| Fgf2 | 6 | 1 ± 0.15 | 5 | 0.66 ± 0.04 | 34 (↓) | 0.078 |
| Fn1 | 6 | 1 ± 0.05 | 6 | 0.93 ± 0.03 | 7 (↓) | 0.240 |
| Hbegf | 6 | 1 ± 0.12 | 6 | 1.02 ± 0.22 | 2 (↑) | 0.944 |
| Icam1 | 6 | 1 ± 0.08 | 6 | 0.93 ± 0.05 | 7 (↓) | 0.461 |
| Ifng | 5 | 1 ± 0.11 | 4 | 0.42 ± 0.13 | 58 (↓) | 0.013 |
| Il1a | 6 | 1 ± 0.06 | 6 | 1.08 ± 0.17 | 8 (↑) | 0.668 |
| Il1b | 6 | 1 ± 0.14 | 6 | 0.63 ± 0.10 | 37 (↓) | 0.060 |
| Il1r1 | 6 | 1 ± 0.09 | 6 | 1.18 ± 0.24 | 18 (↑) | 0.506 |
| Il1r2 | 6 | 1 ± 0.20 | 3 | 1.07 ± 0.20 | 7 (↑) | 0.822 |
| Il2 | 3 | 1 ± 0.59 | 3 | 0.97 ± 0.36 | 3 (↓) | 0.970 |
| Il3 | 4 | 1 ± 0.19 | 2 | 0.38 ± 0.05 | 62 (↓) | NA |
| Il4 | 4 | 1 ± 0.28 | 4 | 0.37 ± 0.03 | 63 (↓) | 0.111 |
| Il5 | 3 | 1 ± 0.44 | 3 | 0.23 ± 0.03 | 77 (↓) | 0.225 |
| Itga2 | 5 | 1 ± 0.13 | 4 | 0.97 ± 0.30 | 3 (↓) | 0.919 |
| Itga5 | 6 | 1 ± 0.09 | 6 | 1.28 ± 0.13 | 28 (↑) | 0.108 |
| Itgax | 6 | 1 ± 0.23 | 6 | 0.81 ± 0.15 | 19 (↓) | 0.500 |
| Itgb2 | 6 | 1 ± 0.08 | 6 | 0.84 ± 0.03 | 16 (↓) | 0.104 |
| Kdr | 6 | 1 ± 0.05 | 6 | 0.97 ± 0.03 | 3 (↓) | 0.693 |
| Klf2 | 0 | NA | 0 | NA | NA | NA |
| Lama1 | 6 | 1 ± 0.10 | 6 | 1.05 ± 0.07 | 5 (↑) | 0.725 |
| Ldlr | 6 | 1 ± 0.05 | 6 | 1.20 ± 0.10 | 20 (↑) | 0.123 |
| Lif | 6 | 1 ± 0.19 | 5 | 0.42 ± 0.08 | 58 (↓) | 0.027 |
| Lpl | 6 | 1 ± 0.11 | 6 | 1.12 ± 0.16 | 12 (↑) | 0.531 |
| Lypla1 | 6 | 1 ± 0.04 | 6 | 1.17 ± 0.02 | 17 (↑) | 0.011 |
| Mmp1a | 6 | 1 ± 0.13 | 6 | 1.17 ± 0.16 | 17 (↑) | 0.436 |
| Mmp3 | 5 | 1 ± 0.35 | 3 | 0.67 ± 0.24 | 33 (↓) | 0.466 |
| Msr1 | 6 | 1 ± 0.04 | 6 | 0.96 ± 0.08 | 4 (↓) | 0.670 |
| Nfkb1 | 6 | 1 ± 0.03 | 6 | 1.07 ± 0.03 | 7 (↑) | 0.102 |
| Npy | 1 | 1 ±NA | 0 | NA | NA | NA |
| Nr1h3 | 6 | 1 ± 0.05 | 6 | 1.16 ± 0.03 | 16 (↑) | 0.034 |
| Pdgfa | 6 | 1 ± 0.10 | 6 | 1.06 ± 0.12 | 6 (↑) | 0.696 |
| Pdgfb | 6 | 1 ± 0.11 | 6 | 0.80 ± 0.04 | 20 (↓) | 0.128 |
| Pdgfrb | 6 | 1 ± 0.07 | 5 | 1.03 ± 0.02 | 3 (↑) | 0.729 |
| Plin2 | 6 | 1 ± 0.09 | 6 | 1.11 ± 0.06 | 11 (↑) | 0.330 |
| Ppara | 6 | 1 ± 0.08 | 6 | 1.13 ± 0.09 | 13 (↑) | 0.317 |
| Ppard | 6 | 1 ± 0.07 | 6 | 0.99 ± 0.02 | 1 (↓) | 0.857 |
| Pparg | 6 | 1 ± 0.10 | 6 | 1.95 ± 0.20 | 95 (↑) | 0.003 |
| Ptgs1 | 6 | 1 ± 0.04 | 6 | 1.01 ± 0.06 | 1 (↑) | 0.935 |
| Rxra | 6 | 1 ± 0.04 | 6 | 1.13 ± 0.06 | 13 (↑) | 0.134 |
| Sele | 5 | 1 ± 0.31 | 6 | 1.08 ± 0.19 | 8 (↑) | 0.842 |
| Sell | 5 | 1 ± 0.45 | 6 | 0.71 ± 0.24 | 29 (↓) | 0.590 |
| Selp | 6 | 1 ± 0.05 | 6 | 0.94 ± 0.06 | 6 (↓) | 0.420 |
| Selpg | 6 | 1 ± 0.11 | 6 | 0.74 ± 0.04 | 26 (↓) | 0.069 |
| Serpinb2 | 4 | 1 ± 0.29 | 4 | 0.45 ± 0.16 | 55 (↓) | 0.164 |
| Serpine1 | 6 | 1 ± 0.09 | 6 | 1.24 ± 0.15 | 24 (↑) | 0.213 |
| Sod1 | 6 | 1 ± 0.05 | 6 | 1.23 ± 0.03 | 23 (↑) | 0.003 |
| Spp1 | 6 | 1 ± 0.10 | 6 | 1.11 ± 0.09 | 11 (↑) | 0.422 |
| Tgfb1 | 6 | 1 ± 0.05 | 6 | 1.09 ± 0.07 | 9 (↑) | 0.310 |
| Tgfb2 | 5 | 1 ± 0.30 | 6 | 0.82 ± 0.15 | 18 (↓) | 0.625 |
| Thbs4 | 5 | 1 ± 0.52 | 0 | NA | NA | NA |
| Tnc | 6 | 1 ± 0.21 | 6 | 1.24 ± 0.19 | 24 (↑) | 0.409 |
| Tnf | 6 | 1 ± 0.20 | 5 | 0.56 ± 0.14 | 44 (↓) | 0.101 |
| Tnfaip3 | 6 | 1 ± 0.12 | 6 | 1.03 ± 0.22 | 3 (↑) | 0.905 |
| Vcam1 | 6 | 1 ± 0.07 | 6 | 0.97 ± 0.08 | 3 (↓) | 0.788 |
| VeffA | 6 | 1 ± 0.09 | 6 | 1.10 ± 0.07 | 10 (↑) | 0.410 |
| Vwf | 6 | 1 ± 0.16 | 6 | 0.71 ± 0.05 | 29 (↓) | 0.127 |
| Actb | 6 | 1 ± 0.02 | 6 | 1.08 ± 0.06 | 8 (↑) | NA |
| B2m | 6 | 1 ± 0.05 | 6 | 0.95 ± 0.01 | 5 (↓) | NA |
| Gapdh | 6 | 1 ± 0.04 | 6 | 0.92 ± 0.03 | 8 (↓) | NA |
| Gusb | 6 | 1 ± 0.04 | 6 | 0.98 ± 0.05 | 2 (↓) | NA |
| Hsp90ab1 | 6 | 1 ± 0.03 | 6 | 1.09 ± 0.04 | 9 (↑) | NA |