TABLE 1.

Mechanisms of quorum sensing modulation in Gram negative bacteria.

Main approach	Mechanism	Type/Target	Result	References
Signal generation	Inhibition of the AI synthesis	LuxI inhibitor	Inhibition of AHL synthesis	Chan et al., 2015
		SAM (S adenozyl methionine) inhibitor	Inhibition of AI-2 synthesis	Taylor et al., 2009
Signal reception	Degradation of the AI	Lactonases	Open the ring of AHLs – inactive AI	See-Too et al., 2018
		Acylases	Cut the lateral acyl chain of AHLs – inactive AI	Utari et al., 2017
	Receptor antagonists	Structural/functional AI antagonists	Inhibition of receptor activation	Chen et al., 2011
	Signal trapping	Clathrate compound	AI sequestration	Taylor et al., 2009
	Suppression of LuxI/LuxR production	Interference RNA	Interference with the translation of LuxI/LuxR mRNA by non-coding small RNA	Chambers and Sauer, 2013