Fig 2.
Analysis of red blood cell (RBC) parameters following SLN124 administration alone, or in combination with deferiprone (DFP). The RBC parameters (A) Haemoglobin concentration (Hb), (B) RBC numbers, (C) RBC distribution width (RDW), (D) Reticulocyte counts (E) Spleen weight and (F) reactive oxygen species (ROS) levels in RBCs measured using dichlorofluorescein diacetate (DCFDA) in either vehicle control or treated groups. Hbbth3+/− and wild type (WT) (~6‐month‐old female) mice were injected twice with 3 mg/kg SLN124 alone or in combination with DFP over a 35‐day period and RBC parameters were measured 21 days after the final injection. Results are represented by box plots, n = 4–9 mice/group. Statistical significance was determined in a Brown–Forsythe test (F*‐test) followed by Dunnett’s T3 post hoc tests against associated vehicle control group and as indicated by the brackets [not statistically significant (ns), P > 0·05, *P ≤ 0·05; **P ≤ 0·01; ***P ≤ 0·001].