Fig 4.
SLN124 reduces splenic zinc (Zn) and magnesium (Mg) overload in Hbbth3/+ mice. Zn and Mg concentrations were measured by laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS), (A) Spleen Zn, (B) Spleen Mg, (C) Liver Zn and (D) Liver Mg from tissue sections obtained 21 days after the final injection from treated and control groups. Results represented by box plot of n = 4–6 mice/group. Statistical significance was determined in a Brown–Forsythe test (F*‐test) followed by Dunnett’s T3 post hoc tests against associated vehicle control group and as indicated by the brackets [not statistically significant (ns), P > 0·05; *P ≤ 0·05; **P ≤ 0·01].