. 2021 Apr 3;17(7):1189–1204. doi: 10.1002/alz.12292

TABLE 3.

Results of multinomial regression models distinguishing ATN stages on the base of regional volumes. Reference (ref.) group is indicated at the top of the table

Ref. group: A–T–N–	A+T–N–				A+T+N–				A+T–N+				A+T+N+
Ref. group: A–T–N–	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)
Basal forebrain	0.0019	0.0006	2.9199	^**0.0035	–0.0006	0.0013	–0.4552	0.6490	–0.0034	0.0018	–1.8584	0.0631	–0.0062	0.0028	–2.2163	^*0.02667
Precentral gyrus	0.0001	0.0001	1.7138	0.0866	0.0003	0.0001	2.3901	^*0.0168	0.0001	0.0001	0.7718	0.4402	0.0000	0.0002	0.1412	0.8877
middle cingulate gyrus	0.0004	0.0002	2.5897	0.0096	0.0005	0.0003	1.6198	0.1053	0.0003	0.0003	0.8713	0.3836	–0.0010	0.0005	–1.9986	^*0.04565
postcentral gyrus	0.0004	0.0001	4.7520	^**<0.0001	0.0003	0.0002	2.0679	^*0.0386	–0.0002	0.0002	–0.9109	0.3623	0.0000	0.0003	0.0040	0.9968
middle occipital gyrus	0.0004	0.0002	2.4888	^*0.0128	0.0000	0.0003	0.1590	0.8737	0.0003	0.0004	0.9349	0.3498	–0.0006	0.0005	–1.2101	0.2262
Amygdala	–0.0009	0.0005	–1.8602	0.0629	–0.0028	0.0008	–3.5115	^**0.0005	–0.0045	0.0009	–4.9321	^**<0.0001	–0.0060	0.0012	–4.9969	^**<0.0001
enthorinal cortex	–0.0007	0.0003	–2.8579	^**0.0043	–0.0010	0.0004	–2.3067	^*0.0211	–0.0021	0.0005	–4.1523	^**<0.0001	–0.0030	0.0007	–4.4222	^**<0.0001
nucleus accumbens	–0.0068	0.0023	–2.9848	^**0.0028	–0.0032	0.0015	–2.0747	^*0.0380	–0.0072	0.0018	–3.9510	^**<0.0001	–0.0068	0.0023	–2.9848	^**0.0028
putamen	0.0003	0.0001	3.9221	^**0.0001	0.0003	0.0001	2.1428	^*0.0321	0.0000	0.0002	–0.0604	0.9518	–0.0001	0.0003	–0.4570	0.6477

Ref. group: A+T–N–	A–T–N–				A+T+N–				A+T–N+				A+T+N+
Ref. group: A+T–N–	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)
basal forebrain					–0.0025	0.0013	–1.8520	0.0640	–0.0052	0.0018	–2.8364	^**0.0046	–0.0081	0.0028	–2.8617	^**0.0042
precentral gyrus					0.0002	0.0001	1.3535	0.1759	0.0000	0.0002	–0.0498	0.9603	–0.0001	0.0002	–0.4140	0.6789
middle cingulate gyrus					0.0001	0.0003	0.1808	0.8565	–0.0001	0.0003	–0.3948	0.6930	–0.0014	0.0005	–2.7642	^**0.0057
postcentral gyrus					–0.0001	0.0002	–0.5258	0.5990	–0.0006	0.0002	–2.8829	^**0.0039	–0.0004	0.0003	–1.4437	0.1488
middle occipital gyrus					–0.0004	0.0003	–1.1370	0.2555	–0.0001	0.0004	–0.1764	0.8600	–0.0011	0.0005	–1.9504	0.0511
amygdala					–0.0019	0.0009	–2.2142	^*0.02682	–0.0036	0.0009	–3.7754	^**0.0002	–0.0051	0.0012	–4.1312	^**<0.0001
enthorinal cortex					–0.0003	0.0005	–0.6053	0.5450	–0.0014	0.0005	–2.6838	^**0.0073	–0.0023	0.0007	–3.3165	^**0.0009
nucleus accumbens					–0.0022	0.0016	–1.3238	0.1856	–0.0062	0.0019	–3.2726	^**0.0011	–0.0058	0.0023	–2.4778	^*0.0132
putamen					0.0000	0.0002	–0.1635	0.8701	–0.0003	0.0002	–1.7736	0.0761	–0.0005	0.0003	–1.6631	0.0963

Ref. group: A+T+N–	A–T–N–				A+T–N–				A+T–N+				A+T+N+
Ref. group: A+T+N–	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)
basal forebrain									–0.0028	0.0021	–1.3166	0.1880	–0.0056	–0.0030	1.8900	0.0588
precentral gyrus									–0.0002	0.0002	–1.0367	0.2999	–0.0003	0.0002	–1.1383	0.2550
middle cingulate gyrus									–0.0002	0.0004	–0.4650	0.6420	–0.0015	0.0006	–2.6465	^**0.0081
postcentral gyrus									–0.0005	0.0002	–2.1051	^*0.0353	–0.0003	0.0003	–1.0610	0.2887
middle occipital gyrus									0.0003	0.0004	0.6618	0.5081	–0.0007	0.0006	–1.1858	0.2357
amygdala									–0.0017	0.0011	–1.5714	0.1161	–0.0032	0.0013	–2.4326	^*0.0150
enthorinal cortex									–0.0011	0.0006	–1.8579	0.0632	–0.0020	0.0008	–2.6803	^**0.0074
nucleus accumbens									–0.0041	0.0022	–1.8866	0.0592	–0.0036	0.0025	–1.4462	0.1481
putamen									–0.0003	0.0002	–1.4316	0.1523	–0.0004	0.0003	–1.4751	0.1402

Ref. group: A+T‐N+	A‐T‐N‐				A+T‐N‐				A+T‐N+				A+T+N+
	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)	Estimate	Std. Error	z‐value	Pr(> \|z\|)
basal forebrain													–0.0028	0.0031	–0.9134	0.3611
precentral gyrus													–0.0001	0.0002	–0.3384	0.7351
middle cingulate gyrus													–0.0013	0.0006	–2.3099	^*0.0209
postcentral gyrus													0.0002	0.0003	0.5570	0.5776
middle occipital gyrus													–0.0010	0.0006	–1.6270	0.1037
amygdala													–0.0015	0.0013	–1.1463	0.2517
enthorinal cortex													–0.0009	0.0008	–1.1340	0.2568
nucleus accumbens													0.0004	0.0026	0.1629	0.8706
putamen													–0.0001	0.0003	–0.3601	0.7188

Notes: Significant results are indicated in dark blue if they indicate a higher volume (i.e., positive regression coefficient) and in light blue if they have a lower volume (i.e., negative regression coefficient). All the analyses were corrected for age, sex, family history of dementia, brain size, and site of data collection. Significance value was set at ‐Pvalue < 0.05 and P‐values were reported as follows.

P < 0.05.

^**

P < 0.01.