TABLE 3.
Fate and reproductive performance of female rats and rabbits administered ADBAC by oral gavage
| CD rats | NZW rabbits | |||||||
|---|---|---|---|---|---|---|---|---|
| Parameter evaluated | ADBAC dose level (mg/kg/day) | ADBAC dose level (mg/kg/day) | ||||||
| 0 (control) | 10 | 30 | 100 | 0 (control) | 1 | 3 | 9 | |
| No. females on study | 25 | 25 | 25 | 25 | 16 | 16 | 16 | 16 |
| No. females that died | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| No. females that delivered earlya | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| No. females that aborted | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| No. females examined at laparotomy | 25 | 25 | 24 | 25 | 16 | 16 | 16 | 16 |
| No. nonpregnant (%) | 0 (0.0)b | 0 (0.0) | 1 (4.2) | 4 (16.0) | 3 (18.8) | 1 (6.3) | 2 (12.5) | 1 (6.3) |
| No. pregnant (%) | 25 (100) | 25 (100) | 23 (95.8) | 21 (84.0) | 13 (81.3) | 15 (93.8) | 14 (87.5) | 15 (93.8) |
| No. females with nonviable implants only | 1 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| No. females with viable implants | 24 (96.0) | 25 (100) | 23 (100) | 21 (100) | 13 (100) | 15 (100) | 14 (100) | 15 (100) |
| Total number pregnant females on study | 25 (100) | 25 (100) | 24 (96.0) | 21 (84.0) | 13 (81.3) | 15 (93.8) | 14 (87.5) | 15 (93.8) |
Abbreviations: ADBAC, alkyl dimethyl benzyl ammonium chloride.
a
Female that delivered early was removed from study.
b
Values are presented as number of females and percent (%) in parentheses.