Table 5.
Confusion matrix and statistical measures of the MYBPC3 NCSS variants
| Tool | Missing values | TP | FP | TN | FN | Accuracy (%) | PPV (%) | Sensitivity (%) | Specificity (%) | NPV (%) | MCC |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Alamut Consensus 3/4 | 0 | 23 | 4 | 23 | 11 | 75 | 85 | 68 | 85 | 68 | 0.53 |
| CADD | 0 | 21 | 8 | 19 | 13 | 66 | 72 | 62 | 70 | 59 | 0.32 |
| DSSP | 0 | 22 | 10 | 17 | 12 | 64 | 69 | 65 | 63 | 59 | 0.28 |
| GeneSplicer | 0 | 25 | 6 | 21 | 9 | 75 | 81 | 74 | 78 | 70 | 0.51 |
| MaxEntScan | 0 | 24 | 6 |
21 |
10 | 74 | 80 | 71 | 78 | 68 | 0.48 |
| MMSplice | 0 | 25 | 6 | 21 | 9 | 75 | 81 | 74 | 78 | 70 | 0.51 |
| NNSPLICE | 0 | 23 | 6 | 21 | 11 | 72 | 79 | 68 | 78 | 66 | 0.45 |
| Spidex | 3 | 20 | 9 | 18 | 14 | 62 | 69 | 59 | 67 | 56 | 0.25 |
| SpliceAI | 0 | 22 | 8 | 19 | 12 | 67 | 73 | 65 | 70 | 61 | 0.35 |
| SpliceRover | 0 | 22 | 9 | 18 | 12 | 66 | 71 | 65 | 67 | 60 | 0.31 |
| SpliceSiteFinder‐like | 0 | 25 | 6 | 21 | 9 | 75 | 81 | 74 | 78 | 70 | 0.51 |
Abbreviations: FN, false negatives; FP, false positives; MCC, Mathew's correlation coefficient; NPV, negative predictive value; PPV, positive predictive value; TN, true negatives; TP, true positives.