TABLE 3.
Outcome for 20 cats diagnosed with diabetic ketoacidosis and treated with the CRI‐ or the glargine‐protocol
| CRI‐group (n = 10) | Glargine‐group (n = 10) | P‐ value | |
|---|---|---|---|
| Number of cats that survived to discharge | 8 | 9 | 1.000 |
| Time to discharge (h) | 172 (91‐221) | 140 (51‐173) | 0.033 |
| Number of cats with spontaneous food intake | 9 | 9 | 1.000 |
| Time to first spontaneous food intake (h) | 54 (6‐132) | 26 (12‐54) | 0.073 |
| Number of cats with improvement of hyperglycemia (< 1.6% of basal) | 10 | 10 | 1.000 |
| Time to improvement of hyperglycemia (h) | 6 (2‐14) | 2 (2‐6) | 0.018 |
| Number of cats with resolution of hyperglycemia (< 13.9 mmol/L [250 mg/dL]) | 8 | 9 | 1.000 |
| Time to resolution of hyperglycemia (h) | 10 (2‐18) | 6 (2‐22) | 0.266 |
| Decrease of glucose (mmol/L)/h until glucose < 13.9 mmol/L | 0.9 (0.4‐4.1) | 1.1 (0.6‐3.8) | 0.481 |
| Decrease of glucose (mg/dL)/h until glucose < 250 mg/dL | 17 (7‐73) | 19 (11‐69) | 0.481 |
| Number of cats with resolution of acidosis (pH > 7.27) | 8 | 9 | 1.000 |
| Time to resolution of acidosis (h) | 29 (6‐101) | 24 (6‐66) | 0.255 |
| Number of cats with improvement of ketonemia (< 6.4 % of basal) | 10 | 9 | 1.000 |
| Time to improvement of ketonemia (h) | 12 (6‐36) | 12 (6‐36) | 0.687 |
| Number of cats with β‐OHB < 2.55 mmol/L | 10 | 9 | 1.000 |
| Time to β‐OHB < 2.55 mmol/L (h) | 42 (18‐102) | 30 (12‐42) | 0.092 |
| Number of cats with β‐OHB < 2.00 mmol/L | 10 | 9 | 1.000 |
| Time to β‐OHB < 2.00 mmol/L (h) | 42 (18‐108) | 30 (12‐42) | 0.078 |
| Number of cats with severe or moderate hypothermia (< 36.49°C)* | 1 | 0 | 1.000 |
| Number of cats with bradycardia (< 120/min)* | 0 | 1 | 1.000 |
| Lowest glucose (mmol/L)* | 10.6 (7.3‐19.9) | 10.7 (4.44‐16.9) | 0.356 |
| Lowest glucose (mg/dL)* | 191 (132‐358) | 192 (80‐303) | 0.356 |
| Number of cats with hypoglycemia (< 3 mmol/L [< 54 mg/dL])* | 0 | 0 | 1.000 |
| Highest glucose (mmol/L)* | 23.4 (18.4‐31.1) | 23.1 (17.5‐33.2) | 0.905 |
| Highest glucose (mg/dL)* | 421 (332‐561) | 416 (315‐598) | 0.905 |
| Lowest pH* | 7.08 (6.97‐7.31) | 7.17 (7.02‐7.33) | 0.278 |
| Lowest HCO3 (mmol/L)* | 9 (5.7‐17.9) | 10.6 (7.1‐20.9) | 0.447 |
| Lowest potassium (mmol/L)* | 2.3 (1.8‐3.2) | 2.3 (1.8‐4.4) | 1.000 |
| Number of cats with severe hypokalemia (< 3 mmol/L)* | 9 | 8 | 1.000 |
| Lowest phosphorus (mmol/L)* | 0.9 (0.38‐2.41) | 0.83 (0.34‐1.9) | 0.720 |
| Number of cats with severe hypophosphatemia (< 0.485 mmol/L)* | 2 | 2 | 1.000 |
| Highest corrected chloride (mmol/L)* | 118 (114‐124) | 115 (112‐124) | 0.356 |
| Number of cats with hyperchloremia (corrected, > 123 mmol/L)* | 1 | 1 | 1.000 |
| Highest sodium until β‐OHB < 2.55 mmol/L (mmol/L)* | 155 (144‐172) | 156 (142‐174) | 0.720 |
| Number of cats with hypernatremia (> 164 mmol/L)* | 1 | 2 | 1.000 |
| Δ Weight (kg) | 0.1 (‐0.2 to ‐0.3) | 0.1 (‐0.1 to ‐0.36) | 0.733 |
| Δ HCT (L/L) | ‐0.04 (‐0.40 to ‐0.14) | ‐0.07 (‐0.15 to ‐0.02) | 0.286 |
| Δ Total protein (g/L) | ‐7 (‐45 to ‐9) | ‐13 (‐33 to ‐6) | 0.967 |
| Δ Creatinine (μmol/L) | ‐17.7 (‐106.1 to ‐70.7) | ‐8.8 (‐44.2 to 17.7) | 0.531 |
| Δ Alanine aminotransferase (U/L) | 30 (‐483 to ‐758) | 87 (‐151 to ‐825) | 0.541 |
| Number of IM insulin injections | 0 | 4 (1‐12) |
Δ, difference between baseline and discharge.
Data are presented as number of animals or median (range). P < 0.05 is considered significant.
*
Untilβ‐OHB < 2.55 mmol/L, basal results not included.