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. 2021 Mar 23;60(29):15705–15723. doi: 10.1002/anie.202016575

Scheme 4.

Scheme 4

Synthesis of pseudo‐natural products by incubation of nucleophiles with P. crustosum PRB‐2. Exploiting a microorganism to source the reactive ortho‐quinone methide 69 provided access to a total of 15 diverse compounds including chemotypes 7074.