TABLE 3.
Multivariable linear and logistic regression to assess the association between FT4 and measures of the severity and clinical course of hyperemesis gravidarum
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| β | 95% CI | p | β | 95% CI | p | |
| HG severity at baseline | ||||||
| Weight change | −0.13 | −0.29 to 0.04 | 0.13 | −0.14 | −0.35 to 0.06 | 0.16 |
| PUQE‐24 | −0.05 | −0.19 to 0.10 | 0.52 | −0.05 | −0.23 to 0.12 | 0.54 |
| NVPQoL | 0.65 | −0.40 to 1.70 | 0.22 | 0.55 | −0.63 to 1.74 | 0.35 |
| HIS | −0.02 | −0.19 to 0.15 | 0.81 | −0.06 | −0.26 to 0.14 | 0.55 |
| Clinical course of HG | ||||||
| PUQE‐24 1 week after inclusion | −0.03 | −0.21 to 0.15 | 0.72 | 0.01 | −0.21 to 0.23 | 0.94 |
| NVPQoL 1 week after inclusion ∫ | −0.20 | −2.37 to 2.12 | 0.87 | 0.80 | −1.69 to 3.36 | 0.53 |
| HIS 1 week after inclusion | 0.15 | −0.05 to 0.36 | 0.13 | 0.07 | −0.15 to 0.29 | 0.50 |
| Total days of hospital admission for HG ∫ | 2.22 | −0.50 to 5.02 | 0.10 | 3.05 | −0.90 to 7.04 | 0.13 |
| OR | 95% CI | p | OR | 95% CI | p | |
| Readmitted yes or no | 1.03 | 0.95‐1.12 | 0.48 | 1.02 | 0.91‐1.14 | 0.72 |
| Readmitted two or more times | 1.02 | 0.92‐1.14 | 0.67 | 1.09 | 0.96‐1.23 | 0.19 |
A p value <0.05 was considered significant, represented with the therefore corresponding 95% % CI β is the unstandardized regression coefficient. OR is the odds ratio. ∫ is log transformed, back transformed and expressed in % of difference. Weight change is weight at baseline minus prepregnancy weight and can be <0 if women lost weight and can be >0 if women gain weight.
Abbreviations: BMI, body mass index; HG, hyperemesis gravidarum; HIS, Hyperemesis Impact Score; NVPQoL, Nausea and Vomiting in Pregnancy Quality of Life; PUQE‐23, 24‐hour Pregnancy Unique Quantification of Emesis and nausea. A higher HIS or NVPQoL score indicates lower quality of life or higher impact on maternal wellbeing. A higher PUQE‐24 score indicates more severe symptoms.
Measures of HG severity at baseline as outcome: Model 1: univariable regression analysis; Model 2: multivariable regression analysis adjusted for gestational age, age, prepregnancy BMI, ethnicity (western or not) and education level.
Measures of clinical course of HG as outcome: Model 1: univariable regression analysis; Model 2: multivariable regression analysis adjusted for gestational age, age, prepregnancy BMI, weight change at baseline, ethnicity (western or not) and education level.