Table 2.

Literature summary of transgenerational effects of the 13 compounds used in the EDC mixture.

	F3 (Transgenerational)
	Pubertal timing	Fertility, EC, and Folloculogenesis	Hypothalamic effects
			GnRH	Kisspeptin	$\mathrm{E}\mathrm{R}\mathrm{\alpha }$	OXT	TH
Di-n-butyl phthalate	—	—	—	—	—	—	—
Di(2-ethylexyl) phthalate	Rattan et al. 2018b	Pocar et al. 2017; Rattan et al. 2018a, 2018b, 2019; Brehm et al. 2018	—	—	—	—	—
Bisphenol A	Ziv-Gal et al. 2015	Ziv-Gal et al. 2015; Drobna et al. 2018; Berger et al. 2016	—	—	Goldsby et al. 2017	Wolstenholme et al. 2012	—
Vinclozolin	—	Nilsson et al. 2012, 2018	—	—	—	—	Gillette et al. 2015
Procymidon	—	—	—	—	—	—	—
Prochrloraz	—	—	—	—	—	—	—
Linuron	—	—	—	—	—	—	—
Epoxinaxole	—	—	—	—	—	—	—
4-Methyl-benzylidene camphor	—	—	—	—	—	—	—
Octyl methoxycinnamate	—	—	—	—	—	—	—
p,p′-DDE	—	—	—	—	—	—	—
Butylparaben	—	—	—	—	—	—	—
Acetaminophen	—	—	—	—	—	—	—
Phthalate and/or plasticizers mixturesa	Zhou et al. 2017	Manikkam et al. 2012a, 2013; Zhou et al. 2017	—	—	—	—	—

Note: —, no data available; EC, estrous cyclicity; EDC, endocrine-disrupting chemicals; ER, estrogen receptor; GnRH, gonadotrophin-releasing hormone; OXT, oxytocin; p,p′-DDE, dichlorodiphenyldichloroethylene; TH, tyrosine hydroxylase.

^aThe studies used some of the EDCs found in our mixture.