Table 2.

Temperature‐dependent decomposition of compound 1 in DMSO.

Activity measured after 3 months	RT[b]	+4 °C[b]	−20 °C[b]	1 ‐ Old sample[c]
PfIspE IC50 [μm][a]	12±4	16±7	>500	10±3
PK/LDH IC50 [μm][a]	34±4	45±6	n.d.	40±4
EcIspE IC50 [μm][a]	101±14	71±10	>500	32±6
Degradation after 2 months	100%	79%	18%	N/A

[a] Errors given as formal standard error. [b] HRMS chromatograms measured shortly before the assay are given in SI, Figure S7. [c] The control values for the old decomposed sample run at the same time. n.d.: not determined, N/A: not applicable, PK/LDH: pyruvate kinase and lactate dehydrogenase, Pf: Plasmodium falciparum, Ec: Escherichia coli, RT: room temperature.