Table 3.
Time‐dependent decomposition of compound 1 at room temperature.
|
|
PfIspE IC50 [μm] [a] |
PK/LDH IC50 [μm][a] |
||
|---|---|---|---|---|
|
Days of incubation |
DMSO |
ACN |
MeOH |
DMSO |
|
0 |
>500 |
>500 |
>500 |
n.d. |
|
5 |
19±7 |
>500 |
>500 |
n.d. |
|
7 |
24±9 |
>500 |
>500 |
48±16 |
|
9 |
10±4 |
>500 |
>500 |
57±22 |
|
12 |
1±1 |
>500 |
>500 |
2±1 |
|
14 |
10±4 |
>500 |
>500 |
50±11 |
|
16 |
11±4 |
>500 |
>500 |
86±17 |
|
Solvent Blank |
>500 |
>500 |
>500 |
n.d. |
[a] Errors given as formal standard error. PK/LDH: pyruvate kinase and lactate dehydrogenase, Pf: Plasmodium falciparum. n.d.: not determined