Table 4.
The biological data of the SFC‐separated compounds and analytical samples over four days.
|
|
IC50 [μm] [a] |
|||
|---|---|---|---|---|
|
Days of incubation |
PfIspE[b] |
EcIspE |
PK/LDH |
PfNF54 |
|
0 |
>500 |
>500 |
n.d. |
n.d. |
|
1 |
>500 |
>500 |
n.d. |
n.d. |
|
2 |
>500 |
>500 |
n.d. |
3.5±0.3 |
|
3 |
486±20 |
397[c] |
n.d. |
n.d. |
|
4 |
99±23 |
75±16 |
95±21 |
2.7±0.3 |
|
DP1 “380” |
199±26 |
n.d. |
>500 |
n.i. (>20) |
|
DP2 “365” |
59±4 |
n.d. |
37±4 |
2.1±0.2 |
[a] All compounds were dissolved in methanol shortly before the assay. [b] Freshly dissolved compound 1 (PfIspE IC50=>500 μm). [c] Error given as formal standard error. n.d.: not determined, n.i.: no inhibition at the highest concentration tested, PK/LDH: pyruvate kinase and lactate dehydrogenase, Pf: Plasmodium falciparum, Ec: Escherichia coli, DP: decomposition product.