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. 2021 May 5;36(7):1403–1415. doi: 10.1002/jbmr.4303

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© 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig. 8 — Insulin production and signaling. (A) Total pancreatic insulin content assessed by ELISA in whole pancreas homogenates of 6‐week‐old mice. Brackets indicate adjusted p values (Tukey's multiple comparison test) after one‐way ANOVA. (B) Immunoblots of whole‐cell lysates from ear mesenchymal stem cell–derived adipocyte cultures before and after 5 or 30 min of exposure to 1 μg/ml of insulin. (C) Densitometric analysis of immunoblot bands shown in B and Supplemental Figure S5A,B , expressed as pAKT/total Akt ratio. Brackets indicate adjusted p‐values (Tukey's multiple comparison test) after one‐way ANOVA (time, F = 33.82, p < .001; genotype, F = 0.057, p = .815; interaction, F = 0.252, p = .781. Abbreviations: ANOVA, analysis of variance; ELISA, enzyme‐linked immunosorbent assay; pAKT, phosphorylated protein kinase B.