Table 3.

Comparison of demographic and cytokine differences among SFTSV patients relative to the acuity of disease

Characteristics	Mild disease (n = 78)	Severe disease (n = 22)	χ2/t/z	p value
Age, year (mean ± SD)	65.44 ± 9.47	65.50 ± 8.49	0.029	.977
Sex (male)	41 (52.56%)	9 (40.91%)	0.932	.334
n (%)
IL‐6	55.11	133.87	14.429	<.001
	(26.85–99.29)a	(94.95–204.53)
IL‐8	66.26	66.48	1.367	.242
	(65.98–66.84)	(66.12–67.11)
IL‐10	18.80	99.02	14.556	<.001
	(7.36–34.69)	(21.56–159.05)
IP‐10	852.19	1944.40	10.968	.001
	(345.28–1701.48)	(1125.84–2453.77)
MCP‐1	185.51	569.56	6.980	.008
	(76.79–230.37)	(105.40–1283.45)
MIP‐1α	684.26	685.95	2.594	.107
	(682.09–710.71)	(683.95–742.47)
IFN‐γb	27.69(13.33–50.76)	103.08 (51.20–212.72)	19.032	<.001
	(n = 52)	(n = 21)
TGF‐β1	1116.73	588.61	2.661	.103
	(442.4–1628.11)	(409.84–1242.41)
TNF‐αb	44.21(21.93–178.94)	120.50 (48.08–338.22)	1.622	.203
	(n = 12)	(n = 8)
RANTES	1260.07	1134.79	0.020	.680
	(785.09–1687.11)	(815.88–1540.5)

Note: Unit, pg/ml.

Abbreviations: IFN‐γ, interferon‐γ; IL‐6, interleukin‐6; IP‐10, IFN‐inducible protein‐10; MCP‐1, monocyte chemoattractant protein‐1; MIP‐1α, macrophage inflammatory protein‐1α; RANTES, regulated upon activation normal T cell expressed and secreted factor; SFTSV, thrombocytopenia syndrome virus; TNF‐α, tumor necrosis factor‐α; TGF‐β1, transforming growth factor‐β1.

^a Denotes the median (IQ).

^b Denotes there was a lack of data.