Scheme 3.
Synthesis of adenosine amidite 6. Reagents and conditions: I) TBS−Cl, imidazole, DMF, 50 °C. II) Boc2O, DMAP, THF, reflux. III) TFA, H2O, THF, 0 °C. IV) 2‐cyanoethyl‐N,N‐diisopropylchlorophosphoramidite, DIPEA, DCM, rt.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.