Table 2.
Synthesis of MARylated peptides 24–30. The amino acids indicated by bold print are the modification sites.
|
Number |
Sequence |
Yield (%) |
Notes |
|---|---|---|---|
|
24 |
Ac‐PAKSADPrAPAPKKG‐OH |
3.6 |
n.a. |
|
25 |
Ac‐GKSADPrGAALSKKG‐OH |
11 |
n.a. |
|
26 |
Ac‐GKSADPrSGPTSLFAVTVAPPGARG‐OH |
6.1 |
Strenuous coupling of Thr‐7 |
|
27 |
Ac‐GKSSGPTADPrSLF‐OH |
9.5 |
n.a. |
|
28 |
Ac‐KESTADPrLHLVLRL‐OH |
0.94 |
n.a. |
|
29 |
Ac‐PAKCADPrAPAPKKG‐OH |
4.1 |
EDT added in cleavage cocktail |
|
30 |
biotin‐PAKCADPrAPAPKKG‐OH |
1.9 |
tBuOOH was used instead of CSO |