FIGURE 1.

Flow chart of review process. The systematic literature search was conducted on 27 April 2020, using the following Search Builder: narcolepsy[MeSH Major Topic] AND (psychosis OR schizophrenia OR delusion OR bipolar disorder OR safety OR side effect, yielding 187 records. An additional 48 records were identified via reference lists from the 187 selected records, or from supplementary Medline searches (15 papers on mechanisms or adverse effects of drugs used to treat narcolepsy; 12 with relevance to the discussion of the relationship between narcolepsy and psychosis; and 21 with more relevance to discussion of narcolepsy or to psychosis but not their relationship). None of the additional records were cohort or case reports. We list as excluded records those that were identified by systematic search but not selected as eligible for inclusion in the qualitative or quantitative analyses for the reasons cited