TABLE 1.
Plasma and liver characteristics in male L‐G6pc −/− mice and wild‐type littermates in fed state or after an overnight fast
| Parameter | L‐G6pc +/+ fed | L‐G6pc −/− fed | P value | L‐G6pc +/+ fasted | L‐G6pc −/− fasted | P value |
|---|---|---|---|---|---|---|
| Median (range) | Median (range) | Median (range) | Median (range) | |||
| Plasma | ||||||
| Glucose (mmol/L) | 8.6 (6.8‐9.5) | 6.5 (5.6‐9.9) | .126 | 5.0 (3.7‐8.4) | 2.1 (1.1‐2.4) | <.001 |
| Insulin (ng/mL) | 0.4 (0.3‐0.6) | 0.2 (0.1‐0.4) | .009 | 0.3 (0.1‐0.6) | 0.2 (0.1‐0.4) | .328 |
| Glucagon (pg/mL) | 113 (55‐163) | 148 (73‐320) | .429 | 113 (86‐132) | 236 (137‐582) | <.001 |
| Insulin/glucagon ratio | 3.5 (2.6‐5.8) | 1.1 (0.5‐3.2) | .017 | 3.0 (1.1‐4.7) | 0.9 (0.3‐1.8) | .003 |
| Lactate (mmol/L) | 3.2 (2.5‐4.0) | 4.4 (3.7‐4.7) | .052 | 1.8 (1.2‐3.3) | 2.1 (0.9‐3.9) | .328 |
| Triglycerides (mmol/L) | 0.6 (0.4‐0.7) | 1.7 (0.3‐2.7) | .082 | 0.5 (0.4‐0.6) | 3.5 (2.3‐8.3) | <.001 |
| Cholesterol (mmol/L) | 2.1 (1.6‐2.8) | 3.7 (1.7‐4.3) | .030 | 2.3 (2.0‐3.8) | 2.9 (1.6‐3.8) | .195 |
| Liver | ||||||
| G6P (nmol/g) | 406 (339‐505) | 1675 (819‐2306) | .004 | 422 (265‐483) | 2586 (1981‐3457) | <.001 |
| Glycogen (mg/g) | 51 (44‐57) | 66 (53‐77) | .017 | 18 (12‐30) | 54 (46‐62) | <.001 |
Note: Bold values indicate that p‐values <.05.