Table 3.
Univariate analysis for overall survival at 18 months.
| n | Hazard Ratio | 95% confidence interval |
P-value | |
|---|---|---|---|---|
| First line steroids to Pentostatin, days | ||||
| <=10 days | 20 | Reference | ||
| >10 days | 40 | 1.1 | 0.6-2.0 | 0.8 |
| Pentostatin used as | ||||
| second line therapy | 22 | Reference | ||
| third line therapy | 38 | 0.9 | 0.5-1.7 | 0.8 |
| Age at Pentostatin | ||||
| <=60 years | 46 | Reference | ||
| >60 years | 14 | 1.9 | 1.01-3.7 | 0.045 |
| Female-to-male gender Mismatch | ||||
| No | 35 | Reference | ||
| Yes | 25 | 0.7 | 0.2-1.9 | 0.4 |
| Donor type | ||||
| HLA-matched related | 19 | 0.7 | 0.2-2.2 | 0.5 |
| HLA-matched unrelated | 35 | |||
| Haploidentical | 3 | |||
| Cord blood | 3 | |||
| Graft source | ||||
| Bone marrow | 10 | Reference | ||
| Peripheral blood | 46 | 1.3 | 0.6-2.9 | 0.5 |
| Cord blood | 4 | Excluded | ||
| Conditioning | ||||
| Myeloablative | 38 | Reference | ||
| Non-myeloablative | 22 | 1.4 | 0.8-2.6 | 0.2 |
| Overall grade (at diagnosis) | ||||
| Grade 2 | 11 | Reference | ||
| Grade 3-4 | 49 | 1.9 | 0.9-4.3 | 0.1 |
| GVHD organs | ||||
| Skin (Reference no skin) | 12 | 2 | 1.02-4.1 | 0.04 |
| UGI (Reference no UGI) | 27 | 0.95 | 0.5-1.7 | 0.9 |
| LGI (Reference no LGI) | 47 | 0.4 | 0.2-0.8 | 0.01 |
| Liver (Reference no liver) | 26 | 1.9 | 1.05-3.3 | 0.03 |
| GVHD organ combination | ||||
| LGI only | 28 | Reference | ||
| Liver only | 10 | 3.3 | 1.4-7.3 | 0.004 |
| LGI + Liver | 10 | 1.4 | 0.6-3.3 | 0.4 |
| LGI + Liver + Skin | 6 | 3.1 | 1.02-9.6 | 0.05 |
| Skin + LGI | 4 | 2.5 | 0.96-6.3 | 0.06 |
| Skin only | 1 | Excluded | ||
| Skin + Liver | 1 | Excluded |