Fig. 3.

Posterior whole-body coronal microPET/CT images of a NRG mouse bearing s.c. implanted HNSCC PDX at a. 6 h, b. 24 h or c. 48 h p.i. of [⁶⁴Cu]Cu-DOTA-panitumumab F(ab´)₂. The tumour is shown by the white arrow. At 6 h p.i., the mediastinum (blood pool; white arrowhead), liver (blue arrowhead) and kidneys (broken red circles) are visualized, while at 24 and 48 h p.i., the liver was the only normal organ visualized. d. Immunohistochemical staining of the excised tumour demonstrated strong EGFR positivity