Fig. 1.

Results of computer simulations run with complete BioModel for mitochondrial energy metabolism and 3D spatial model for a crista, as described in text.

(A,B) Maps of ADP concentration, [ADP], outside matrix for initial [ADP] of 0.002 ​mM (A) and 0.05 ​mM (B).

(C,D) Plots of [ADP] from a point distal to the crista junction opening to a point proximal to the opening in (A) and (B), respectively.

(E,F) Maps of ANT flux, J(ANT), on the inner membrane corresponding to the [ADP] maps of (A,B).