. 2021 Apr 1;4:163–176. doi: 10.1016/j.crphys.2021.03.005

Table 1.

Variation in [ADP] and ANT flux inside cristae.

MODEL (FIGURE)	K_f (msec⁻¹)	L_CRIS (nm)	[ADP] (mM)		J(ANT) (mol/μm²/ms)
MODEL (FIGURE)	K_f (msec⁻¹)	L_CRIS (nm)	Proximal	Distal	Proximal	Distal
3D TOMO	0.07	580	.002	.009	68	120
(1)			.050	.010	150	118
2D	0.003	320	.037	.016	110	72
(4)			.037	.016	110	72
			.370	.160	114	106
		620	.037	.005	125	38
		620	.370	.055	122	85
3D LAM	0.003	150	.037	.017	108	76
(5,6)		900	.037	.003	137	22
	0.009	150	.037	.022	104	83
		900	.037	.009	119	56
3D TUB	0.003	150	.037	.028	101	90
(5,6)		900	.037	.003	125	18
	0.009	150	.037	.029	100	92
		900	.037	.008	115	49

Gradients of ADP concentration, [ADP], and ANT flux, J(ANT), were established inside cristae during steady state. Values are presented for [ADP] and J(ANT) at the crista openings (proximal) and at the farthest end of the cristae from the openings (distal) for spatial models with cristae of different length, L_CRIS, and different values of the forward rate constant for the surrogate kinase reaction, k_f. 3D TOMO refers to the three-dimensional crista model extracted from an EM tomogram of a mitochondrion (described in text). The other simulations used idealized 2D and 3D spatial models based on those in Fig. 3, Fig. 5. Numbers in parentheses in first column refer to figures in the text with typical results for that spatial model. Abbreviations: LAM, lamellar cristae; TUB, tubular cristae.