Figure 6.

Responses of microglia to AD neuropathology. a The ITC of a control case (M01) demonstrating activated microglia with morphological features consistent with the formation of phagosomes (arrows) responding to peripheral and core elements of an Aβ plaque. b In the ITC of AD cases (M17 pictured), dystrophic microglia were more commonly associated with plaques that contained dense accumulations of dystrophic neurites, however the overall density of dystrophic microglia was inversely correlated with brain pH and not with AD. c–d Conversely, plaques with a lower density of dystrophic neurites were more commonly associated with a cluster of activated microglia (M01 pictured) in both the PMC (c) and ITC (d). Scale bar = 20 μm (a–d)