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. 2021 Aug 12;16(8):e0255869. doi: 10.1371/journal.pone.0255869

Table 8. Studies of measured and estimated glomerular filtration rate in Africa and Europe.

Author Country Number of Participants Cohort Measured GFR Median Bias With Ethnicity Correction Median Bias Without Ethnicity Correction % estimates within 30% mGFR with ethnicity correction % estimates within 30% mGFR without ethnicity correcton
MDRD
Agoons [45] Cameroon 51 Type 2 Diabetes Mellitus Median mGFR 69.0 mL/min/1.73m 24-hour creatinine clearance -13.00% -0.30% - -
Arlet [46] African French 64 Sickle cell disease patients Median mGFR 112.5 mL/min/1.73m Iohexol Median difference in eGFR and mGFR 49.3 [24.7–64.8] Median difference in eGFR and mGFR 19.9 [4.9–32.9] - -
Bukabau [16] Democratic Republic of Congo 93 Healthy Adults Mean mGFR 92.0 ± 17.2 mL/min/1.73m Iohexol Median difference in eGFR and mGFR 13.6 [8.0–19.2] Median difference in eGFR and mGFR -4.9 [-9.6; -0.2] 79.6% 86.0%
Madala [44] South Africa   CKD Outpatients 70.3% mGFR <60 mL/min 99m-Tc-DTPA eGFR <30: 39.2%; 30–59: 5.3%; >60: 19.3% 29.2% 17.1% 38.0% 53.3% 62.5% 35.1% 36.1% 65.2% 68.8%
Moodley [36] South Africa 188 Nuclear Medicine Studies 99m-Tc-DTPA - Mean bias: Female 16.4%; Male 29.1% - Mean bias: Female 49.9%; Male 54.3%
Seape [15] South Africa 97 Black HIV patients 51Cr-EDTA-GFR 38.40% 14.20% 43.30% 59.80%
Van Deventer [38] South Africa 100 Healthy Adults 51Cr-EDTA-GFR 27% 5% - -
Wyatt [47] Kenya 99 HIV patients Iohexol 18% -3% 73% 83%
CKD-EPI
Agoons Cameroon 51 Type 2 Diabetes Mellitus Median mGFR 69.0 mL/min/1.73m 24-hour creatinine clearance -8.5 1.7 - -
Arlet African French 64 Sickle cell disease patients Median mGFR 112.5 mL/min/1.73m Iohexol Median difference in eGFR and mGFR 30.5 [16.5–44.3] Median difference in eGFR and mGFR [-0.7; 24.8] - -
Bukabau Democratic Republic of Congo 93 Healthy Adults Mean mGFR 92.0 ± 17.2 mL/min/1.73m Iohexol 17.20% 2.30% 73.10% 81.70%
Flamant [11] African French 302 CKD Patients Mean mGFR 57.6 mL/min/1.73m 51Cr-EDTA-GFR 11.90% - 74.80% -
Moodley South Africa 188 Nuclear Medicine Studies 99m-Tc-DTPA Female 31.5% Male 39.4% Femle 13.5% Male 20.2% Femle 46.7% Male 45.7% Femle 53.3% Male 54.3%
Seape South Africa 97 Black HIV patients 51Cr-EDTA-GFR 33.70% 15.30% 41.20% 62.90%
Wyatt Kenya 99 HIV patients Iohexol 10% -4% 82% 85%