Table 7. Scenario 2 deterministic sensitivity analysis results.
| Parameter | Parameter value | Difference in costs (USD) | Difference in costs (R) | Incremental benefits | Dominance break off point | ICER |
|---|---|---|---|---|---|---|
| Base case | N/A | -303 | -5,255 | 0.0134 | $308 | Mouthwash dominates |
| Relative Risk Reduction | ||||||
| RRR | 0.2 | -211 | -3,661 | 0.0090 | $217 | Mouthwash dominates |
| 0.1 | -108 | -1,874 | 0.0045 | $114 | Mouthwash dominates | |
| 0.05 | -52 | -908 | 0.0022 | $58 | Mouthwash dominates | |
| 0.01 | -6 | -100 | 0.0004 | $11 | Mouthwash dominates | |
| Costs | ||||||
| Pneumonia | $121 | -4 | -72 | 0.0004 | N/A | Mouthwash dominates |
| $5,804 | -7 | -116 | 0.0004 | N/A | Mouthwash dominates | |
| Bed day | $57 | -6 | -101 | 0.0004 | N/A | Mouthwash dominates |
| $85 | -6 | -100 | 0.0004 | N/A | Mouthwash dominates | |
| Probabilities | ||||||
| No-Mouthwash | ||||||
| Pneumonia | 0.03 | 209 | 3,627 | -0.0144 | N/A | No-mouthwash dominates |
| 0.05 | -81 | -1,403 | 0.0056 | N/A | Mouthwash dominates | |
| Pneumonia, critical care unit | 0.43 | 101 | 1,758 | 0.0004 | N/A | $226,102 |
| 0.64 | -106 | -1,840 | 0.0004 | N/A | Mouthwash dominates | |
| Pneumonia, mechanical ventilation | 0.10 | 4 | 73 | 0.0004 | N/A | $9,348 |
| 0.40 | -15 | -268 | 0.0004 | N/A | Mouthwash dominates | |
| No Pneumonia, critical care unit | 0.08 | 272 | 4,723 | 0.0004 | N/A | $607,303 |
| 0.11 | -284 | -4,924 | 0.0004 | N/A | Mouthwash dominates | |
| No Pneumonia, mechanical ventilation | 0.14 | 14 | 239 | 0.0004 | N/A | $30,731 |
| 0.30 | -18 | -318 | 0.0004 | N/A | Mouthwash dominates | |
| No Pneumonia, no mechanical ventilation, dead | 0.010 | -6 | -100 | 0.0004 | N/A | Mouthwash dominates |
| 0.080 | -6 | -100 | 0.0004 | N/A | Mouthwash dominates | |
| Mouthwash | ||||||
| Pneumonia | 0.03 | -212 | -3,684 | 0.0148 | N/A | Mouthwash dominates |
| 0.05 | 75 | 1,303 | -0.0052 | N/A | No-mouthwash dominates | |
| Pneumonia, critical care unit | 0.43 | -107 | -1,849 | 0.0004 | N/A | Mouthwash dominates |
| 0.64 | 99 | 1,713 | 0.0004 | N/A | $220,284 | |
| Pneumonia, MV | 0.10 | -15 | -267 | 0.0004 | N/A | Mouthwash dominates |
| 0.40 | 4 | 67 | 0.0004 | N/A | $8,551 | |
| No Pneumonia, critical care unit | 0.08 | -284 | -4,928 | 0.0004 | N/A | Mouthwash dominates |
| 0.11 | 272 | 4,727 | 0.0004 | N/A | $607,818 | |
| No Pneumonia, MV | 0.14 | -26 | -448 | 0.0004 | N/A | Mouthwash dominates |
| 0.30 | 6 | 109 | 0.0004 | N/A | $13,963 | |
| No Pneumonia, no MV, dead | 0.010 | -6 | -100 | 0.0004 | N/A | Mouthwash dominates |
| 0.080 | -6 | -100 | 0.0004 | N/A | Mouthwash dominates | |
| Length of stay (mean days) | ||||||
| No Mouthwash | ||||||
| General ward | 9.09 | -2 | -43 | 0.0004 | 7.41 | Mouthwash dominates |
| 13.63 | -9 | -158 | 0.0004 | Mouthwash dominate | ||
| Critical care unit | 15.19 | 22 | 386 | 0.0004 | 18.21 | $49,617 |
| 22.79 | -34 | -587 | 0.0004 | Mouthwash dominates | ||
| MV | 16.90 | -3 | -60 | 0.0004 | 10.50 | Mouthwash dominates |
| 25.34 | -8 | -140 | 0.0004 | Mouthwash dominates | ||
| Mouthwash | ||||||
| General ward | 9.09 | -9 | -158 | 0.0004 | 15.30 | Mouthwash dominates |
| 13.63 | -2 | -43 | 0.0004 | Mouthwash dominates | ||
| Critical care unit | 15.19 | -33 | -572 | 0.0004 | 19.80 | Mouthwash dominates |
| 22.79 | 21 | 371 | 0.0004 | $47,760 | ||
| MV | 16.90 | -8 | -139 | 0.0004 | 32.07 | Mouthwash dominate |
| 25.34 | -4 | -62 | 0.0004 | Mouthwash dominates | ||
| Extreme case analysis | ||||||
| No patient on MV | N/A | -6 | -101 | 0.0004 | N/A | Mouthwash dominates |
| Best case scenario | N/A | -283 | -4,917 | 0.0148 | N/A | Mouthwash dominates |
| Worst case scenario | N/A | 249 | 4,322 | -0.0052 | N/A | No-mouthwash dominate |
*MV = mechanical ventilation.